1) Although micronized progesterone has fewer side effects than medroxyprogesterone, it provides less endometrial protection than its synthetic counterpart. True or False
2) Recent Deep Vein Thrombosis or a positive family history of clotting disorder is a contraindication to all estrogen replacement. True or False
3) Equilin and equilinin are two natural hormones that have beneficial effects in both arteries and veins. True or False
4) The main side effect of slow-release (SL) micronized progesterone is somnolence (sleepiness) which limits the dose to no more than 100mg/day. True or False
5) Cal/Mag is beneficial for PMS. True or False

Answers:
1) False. As long as serum progesterone levels of 20-30 mcg/dl are maintained, adequate protection is assured. 2) False. Oral estrogen increases clotting factors by first pass liver metabolism, but multiple studies demonstrate that transdermals do not increase clotting factors and have never increased clotting risks, DVT, or PE. 3) False. These are the main equine estrogens associated with increased clotting. 4) False. Only oral progesterone causes somnolence, not the SL. It is due to metabolites from first pass metabolism. Doses range 100-400 mg/day of the SL forms. 5) True.