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Jeppsen-Osguthorpe
Study
Effectiveness of the Asyra (EDS) in assessing
sub-physiologic Thyroid levels (free T3 of less than
4.0) in women 35 to 65 years of age.
Conclusion
Because the majority of the effects of hypothyroidism can be
prevented or reversed by thyroid hormone replacement, the clinician
must be able to identify those patients who are most at risk for
developing hypothyroidism and recognize the subtle clinical signs
and symptoms of the disease. It is important to consider that there
may be a wide variation in the clinical presentation. Routine
screening programs identify hypothyroid neonates, so that treatment
can be started shortly after birth. Hypothyroidism should be
suspected when there is evidence of underlying thyroid, pituitary,
or hypothalamic disease or when the patient has been previously
exposed to any treatment that may disrupt the function of the
hypothalamic-pituitary-thyroid axis. Laboratory assessment after an
EDS assessment of thyroid function is the optimal approach to
confirm the diagnosis. However, thyroid function tests may not
accurately reflect thyroid status in individuals with nonthyroidal
illness, conditions that affect thyroid binding to plasma proteins,
and thyroid hormone resistance. Consequently, the clinician must
integrate clinical observations, EDS findings and laboratory data
to properly diagnose and manage the hypothyroid patient. The goals
of thyroid hormone replacement are to relieve symptoms. Many
decades of experience show the efficacy of treating hypothyroidism
with L-T3 alone.
This study has demonstrated the effectiveness of
ElectroDermal screening with both the clinical and laboratory
diagnosis in 500 patients with sub-physiologic hypothyroid have
been compared to 100 normal age adjusted control subjects. The
correlation between the EDS measured abnormalities, using standard
deviation (SDI) criteria and patients with sub-physiologic
hypothyroid state was statistically significant at 99.5% with a
P< 0.005. Thus EDS has demonstrated its effectiveness as a
valuable tool for the analysis and diagnoses of sub-physiologic
hypothyroid levels.
Synopsis of Study
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